A Complete Study on the Effects of Manuka Honey

Manuka Honey has been known for centuries in the New Zealand experience. In recent decades, interest has also grown on the scientific side. With Manuka honey, a remedy has been found which has a natural effect and does not cause any significant side effects.

To understand the effect of the honey, one must first consider the manuka plant, also known just as Manuka or South See Marte. The inhabitants of New Zealand took advantage of Manuka has always been to Verarztung their warriors. From the leaves and bark, infusions and pastes were spread, with which burns, wounds, and inflammations were treated, but also gastrointestinal complaints, colds, and skin hardships were provided.

All these complaints were able to cure the Maori with a Sud from different plant parts. Today it is known that the healing effect is due to the contained essential oils, the methylglyoxal content and other plants, which show antibacterial and anti-inflammatory effects. 

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Discovery of the healing effect of Manuka honey

For the first time, Manuka's therapeutic effect was discovered by the botanist Joseph Banks (1742-1820), a native of England, who accompanied James Cook on a circumnavigation around the world in the middle of the eighteenth century. The Manuka honey, on the other hand, is a discovery of the modern age (19th century).

It has been around 30 years since scientists have been working on Manuka honey and its healing effects. For the first time, the substance methylglyoxal was responsible for the high antibacterial effect at the TU Dresden. Meanwhile, the Manuka honey is researched in clinical studies and applied to certain diseases.

Honey has an amazing effect on our health. Science has also come to this realization. Thus, numerous studies are being conducted on the impact, especially on the effect of Manuka honey, because Manuka honey from New Zealand has an incomparably high potential of antibacterial effect, which goes far beyond the usual.

Albert Einstein

Once the bees disappear from the earth, man has only four years to live. No bees, no pollination, no more plants, no more animals, no more people.

Manuka honey in the interest of science

The anti-inflammatory properties of honey were already known to the ancient Egyptians. And also in the world wars wounds were successfully treated with honey shakes. But when the first antibiotics came onto the market, honey as a remedy was always pushed out. Since, however, many germs have formed resistance to antibiotics today, the tried and tested solutions are brought back into the forefront. At the University of Bonn, medical honey products based on manuka honey have been used for some years. The results of the wound treatment are extremely satisfactory. The effect of the manuka honey in some cases even exceeds that of antibiotics.

To the effectiveness of Manuka honey, there is a significant number of scientific studies. These are a few dozen investigations, mainly conducted over the past ten years, many of which were recently completed. An overview of this variety of studies can be found at the US National Library of Medicine, National Institute of Health.

Medihoney ™ (medical honey) as a special form of Manuka honey

The promising results of the studies on Manuka honey over the past 15 years have prompted scientists to improve the Manuka Honey for external medical purposes, specifically for wound care and wound care. The so-called Medihoney ™ has been CE-certified since 2004 and approved for medical use in the European area. Medihoney meets the medical criteria for wound care such as purity, impact and biological safety. The difference of this medical honey and natural Manuka honey is the subsequent treatment with gamma radiation for sterilization.

Studies on the effect of Manuka Honey

Antibacterial effect of Manuka honey

Australian researchers were able to demonstrate in a study already in 2009 that Manuka honey (in combination with Jellybush honey) is more suitable for the treatment of superficial wounds than antibiotics. Manuka honey has the advantage over antibiotics that the pathogens do not form resistances. Thus even wounds that are populated with multiresistant bacteria can be effectively treated.

In the Technical University of Dresden (TUD) succeeded, the concentration of sugar degradation product in different Manuka honey from New Zealand to investigate and "in vitro" the antibacterial effect quantitatively detect. For this purpose, the scientists used the HPLC method (high-performance liquid chromatography) and found a methylglyoxal content up to 100-fold higher than in other honey varieties. The heat resistance of methylglyoxal was also determined. A report from the magazine " labor and more " reports on this.

But not only in Dresden is researched, but also in the University of Waikato in New Zealand studies are made to Manuka honey. The researchers in New Zealand found that different anions (negatively charged ions) in the freshly collected honey can only produce the methylglyoxal by withdrawing the moisture of the ingredient dihydroxyacetone. Further research revealed that the Methylglyoxal content in mature manuka honey, depending on their origin, varies. This finding is used to breed and cultivate manuka plants with a high active ingredient content.

The antibacterial effect of Manuka honey has been demonstrated in several other studies. In particular, the bactericidal effect of Manuka honey on wounds was investigated in a study of 2013 and 2014 and the honey was also confirmed an antibiotic effect in particular on wounds.

The sugar degradation product methylglyoxal (MGO) is responsible for the antibacterial effect of Manuka honey. The MGO content makes Manuka honey so effective in treating wound healing problems.

Antiobiotic effect of Manuka honey

In a comprehensive study, the University of Bonn, together with the clinics in Dusseldorf, Homburg, and Berlin, will gather experience and data on the wound healing of problem wounds with medical honey. To this end, 100 disease processes are to be documented and evaluated. The honey used consists of two honey varieties, one of the two is the active antibacterial Manuka honey. It bears the CE mark and is subject to regular quality controls.

Kai Sofka, specialist in the University Hospital of Bonn

Dead tissue is repelled faster, and the wound heals faster. In addition, the change in the association makes for less pain because the envelopes can be easily removed without hurting the newly formed skin layers.

The so-called "hospital nuclei" are germs that feel comfortable, especially in hospitals and the prevailing conditions. They are resistant to the usual antibiotics. The University Clinic in Bonn, under the supervision of Doctor Arne Simon and the specialist Kai Sofka, reports that they use honey in the field of hematology and oncology. Your experience with the product shows that children with cancer develop a better wound healing under Manuka honey. The medical experts speak in this report that some USA hospitals use the medicinal honey (media honey (TM)) in the wound care without mentioning the names of the clinics. The year 2002 also marks an important year in Great Britain about the disease pathogens MRSA and MS SA. The feared hospitals had cost 20,000 lives in Great Britain alone, millions of people worldwide. Prof. Liz Harry of the University of Technology in Sydney (Australia) found that Manuka honey, besides the excellent` antimicrobial effect, still has an inspiring ability.

Prof. Liz Harry from the University of Technology in Sydney

Manuka honey can make the previously resistant bacteria MRSA re receptive to antibiotics. When antibiotics and Manuka honey are administered simultaneously, Manuka Honey prevents the MRSA bacteria from becoming resistant to Manuka Honey.

The investigation also stated that:

  • Under laboratory conditions, it was found that the bacteria did not develop any resistance to the influence of Manuka honey.
  • If the Super Kim MRSA is treated only with a particular antibiotic (rifampicin), it will be resistant very quickly.
  • The combination of antibiotics and Manuka honey gives you the best results.

The above points are significant findings of the efficacy of Manuka honey. Because if the dangerous hospitals are resistant to the usual antibiotics and there are no antibiotics that act against them, then Manuka is an excellent option and should not be considered as a "last attempt" in the treatment. This opinion is at least Prof. Liz Harry, and affected patients can also benefit from the findings.

Manuka honey against biofilms (bacteria layers)

Under biofilm bacteria, layers are to understand that are problematic, especially in hospitals. These bacterial layers can be located, for example, on catheters, where they can lead to infection in the patient. A research group has succeeded in preventing 70% of the bacteria (E. coli biofilms) from adhering to the catheter after the use of an aqueous manuka honey solution. Until now, only laboratory tests were carried out. But due to the promising results, it is hoped that the Manuka solution will soon be used in hospitals to clean catheters.

Manuka honey in diabetic foot syndrome

Manuka honey is currently under investigation in a clinic in Berlin (Berlin Havelhöhe) in clinical trials in diabetic foot syndrome. The diabetic foot syndrome is a complex problem. The tissue is severely affected, the supply of the cells strongly disturbed and interrupted. Affected areas are no longer supplied with blood so that bacteria can spread and continue their decomposition process. The doctors in the Berlin clinic provide the affected patients with Manuka honey.

The honey is applied to the wound with a moist wound dressing and thus creates a moist wound environment, which disinfects itself. This results in faster wound healing and less scarring in the patients. Also, the use of Manuka honey shows that new vessels are formed so that the supply of the previously underserved areas can be restored.

The Havelhöhe clinic in Berlin expects the treatment with Manuka honey pads to be responsible for the fact that in many patients with diabetes amputation in the lower limb or thigh area could be prevented. The clinic does not work with the medical product Medihoney (TM), but with commercial Manuka food honeycomb MGO100 +. Manuka honey MGO400 + was used for short periods. The aim was to speed up the healing process. But the high methylglyoxal content in the Manuka Honey MGO400 + caused severe pain. Therefore, the doctors returned to the MGO100 + concentration in the treatment.

The German Society for Wound Healing and Surgical Treatment rejects a treatment of chronic wounds with Manuka honey, which can be read in their S3 Guideline. This is because, despite the good experiences and successes, only a small number of clinical and animal experiments have been carried out.

Manuka Honey in nasal mucousitis

In 2009, a Canadian study from Ottawa was released, confirming that medical manuka honey can heal radiation-damaged tissue more quickly. This statement is strengthened by another study from Sydney, Australia. This means that a chronic nasal mucosa inflammation can be inhibited by the use of Manuka honey. The honey makes it possible to eliminate one hundred percent of the responsible pathogens (MSSA and MRSA) in an antibiotic-sensitive as well as an antibiotic-resistant condition under laboratory conditions. In vitro, the value decreased to 82% for MSSA and 63% for MRSA. However, the study did not clarify why this functioned.

Manuka honey and yeast

Yeast fungi can cause rejection of the transplanted organ in transplant patients. In 2007, an American patient who had received two new kidneys suffered an infection with a rare yeast fungus. The infection was already reaching the spinal cord, and aggressive antibiotics did not seem to be able to contain this disease. In the course of the treatment, the patient developed a wetting wound on the leg. The limbs were swollen, yellow, and green. The discolored wound reached from the knee down to the ankle. The doctors diagnosed that the leg was no longer to be saved but amputated . In the first step, the already dead skin should be cut off and replaced by the skin graft, then the amputation should be performed. Before this radical intervention was made, a nurse suggested the treatment with a wound dressing from Medihoney. In America, wound dressings were recently approved as a medical device. The Manuka honey worked and within 14 days completely healed the open wound. As a result, the doctors were able to save the leg, and the patient is now healthy.

Propolis as an important supporter of manuka honey

Due to the high content of vital substances in the propolis from manuka beehives, researchers were attracted to the natural product. Propolis contains resin, wax, essential oils, flower pollen, amino acids, minerals, iron, copper, magnesium, manganese, selenium, zinc, vitamin A, vitamin C, vitamin E, vitamin H, vitamin B complex. Besides, a considerable amount of flavonoids.

Flavonoids can largely neutralize carcinogenic substances by their inhibitory and blockade mechanisms. Also, the ingredients in propolis have a good synergetic effect. It has even been reported that the active ingredients have been responsible for the spontaneous healing of damaged tumor cells.

Scientists are looking for the main active ingredient that causes a particular pharmacological property. In the case of propolis and manuka honey, they are therefore looking for the central substance which they can isolate and synthesize to make the effect controllable from a scientific point of view. If science can find this drug, you can have it patented and mass produced.

In the attempts to isolate the drug, Dr. Hiroshi Maruta from the University Hospital Hamburg-Eppendorf insists that CAPE is contained in Propolis. CAPE is phenyl sulfonate, and it is responsible for the inhibition of cancer cell growth.

CAPE's salary is demonstrably highest in the New Zealand Manuka Propolis (compared to other honey varieties), and Dr. Maruta's studies show that the Propolis Liquid 25% Bio 30 used in New Zealand attacks bacteria, fungi, and viruses from New Zealand. Lippenherpes was thus also curbed and, according to his records, it was less often a re-infection. He also noted that preventive treatment with this particular propolis product protects against lip herpes.

Propolis is compared with acetylsalicylic acid (aspirin) given its anti-inflammatory properties. The efficacy in Manuka honey, however, is twice as high, but in contrast to aspirin does not show any side effects. If Propolis is used with Manuka honey, inflammatory herds can be efficiently absorbed inside and outside the human body. These are the results of Dr. Maruta's bottom line. His records, however, have not been in the form of a scientific study, but in the context of his research. This is a difference in the neutrality and reliability of its collected data, which is defined by classical clinical studies by definition.

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